An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution

Placental development and imprinting co-evolved with parental conflict over resource distribution to mammalian offspring. The imprinted genes, IGF2 and IGF2R, code for the growth promoter insulin-like growth factor 2 and its binding inhibitor, mannose 6-phosphate/IGF2 receptor, respectively. M6P/IGF...

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Veröffentlicht in:Science
Hauptverfasser: Williams, Christopher, Hoppe, Hans-Jürgen, Rezgui, Dellel, Strickland, Madeleine, Forbes, Briony E., Grutzner, Frank, Frago, Susana, Ellis, Rosamund Z., Wattana-Amorn, Pakorn, Prince, Stuart N., Zaccheo, Oliver J., Nolan, Catherine M., Mungall, Andrew J., Jones, E. Yvonne, Crump, Matthew P., Hassan, A. Bassim
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4658703/
https://ncbi.nlm.nih.gov/pubmed/23197533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1228633
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