Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist

Among the 15 extracellular domains of the mannose 6-phosphate/insulin-like growth factor-2 receptor (M6P/IGF2R), domain 11 has evolved a binding site for IGF2 to negatively regulate ligand bioavailability and mammalian growth. Despite the highly evolved structural loops of the IGF2:domain 11 binding...

詳細記述

保存先:
書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Frago, Susana, Nicholls, Ryan D., Strickland, Madeleine, Hughes, Jennifer, Williams, Christopher, Garner, Lee, Surakhy, Mirvat, Maclean, Rory, Rezgui, Dellel, Prince, Stuart N., Zaccheo, Oliver J., Ebner, Daniel, Sanegre, Sabina, Yu, Sheng, Buffa, Francesca M., Crump, Matthew P., Hassan, Andrew Bassim
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2016
主題:
PNAS Plus
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878476/
https://ncbi.nlm.nih.gov/pubmed/27140600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513023113
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