Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist

Among the 15 extracellular domains of the mannose 6-phosphate/insulin-like growth factor-2 receptor (M6P/IGF2R), domain 11 has evolved a binding site for IGF2 to negatively regulate ligand bioavailability and mammalian growth. Despite the highly evolved structural loops of the IGF2:domain 11 binding...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Frago, Susana, Nicholls, Ryan D., Strickland, Madeleine, Hughes, Jennifer, Williams, Christopher, Garner, Lee, Surakhy, Mirvat, Maclean, Rory, Rezgui, Dellel, Prince, Stuart N., Zaccheo, Oliver J., Ebner, Daniel, Sanegre, Sabina, Yu, Sheng, Buffa, Francesca M., Crump, Matthew P., Hassan, Andrew Bassim
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878476/
https://ncbi.nlm.nih.gov/pubmed/27140600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513023113
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados