Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist

Among the 15 extracellular domains of the mannose 6-phosphate/insulin-like growth factor-2 receptor (M6P/IGF2R), domain 11 has evolved a binding site for IGF2 to negatively regulate ligand bioavailability and mammalian growth. Despite the highly evolved structural loops of the IGF2:domain 11 binding...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Frago, Susana, Nicholls, Ryan D., Strickland, Madeleine, Hughes, Jennifer, Williams, Christopher, Garner, Lee, Surakhy, Mirvat, Maclean, Rory, Rezgui, Dellel, Prince, Stuart N., Zaccheo, Oliver J., Ebner, Daniel, Sanegre, Sabina, Yu, Sheng, Buffa, Francesca M., Crump, Matthew P., Hassan, Andrew Bassim
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2016
Предметы:
PNAS Plus
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878476/
https://ncbi.nlm.nih.gov/pubmed/27140600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513023113
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