Structure and functional analysis of the IGF-II/IGF2R interaction

Embryonic development and normal growth require exquisite control of insulin-like growth factors (IGFs). In mammals the extracellular region of the cation-independent mannose-6-phosphate receptor has gained an IGF-II-binding function and is termed type II IGF receptor (IGF2R). IGF2R sequesters IGF-I...

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Main Authors: Brown, James, Delaine, Carlie, Zaccheo, Oliver J, Siebold, Christian, Gilbert, Robert J, van Boxel, Gijs, Denley, Adam, Wallace, John C, Hassan, A Bassim, Forbes, Briony E, Jones, E Yvonne
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206120/
https://ncbi.nlm.nih.gov/pubmed/18046459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601938
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