Phagocyte-like NADPH oxidase (Nox2) promotes activation of p38MAPK in pancreatic β-cells under glucotoxic conditions: Evidence for a requisite role of Ras-related C3 botulinum toxin substrate 1 (Rac1)

It is well established that glucotoxicity (caused by high glucose concentrations; HG) underlies pathogenesis of islet dysfunction in diabetes. We have recently demonstrated that Nox2 plays a requisite role in the generation of reactive oxygen species (ROS) under HG conditions, resulting in mitochond...

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Veröffentlicht in:Biochem Pharmacol
Hauptverfasser: Sidarala, Vaibhav, Veluthakal, Rajakrishnan, Syeda, Khadija, Vlaar, Cornelis, Newsholme, Philip, Kowluru, Anjaneyulu
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684092/
https://ncbi.nlm.nih.gov/pubmed/25881746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2015.04.001
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