Exposure to chronic hyperglycemic conditions results in Ras-related C3 botulinum toxin substrate 1 (Rac1)-mediated activation of p53 and ATM kinase in pancreatic β-cells

Eitemau Tebyg

• EHT 1864, a small molecule inhibitor of Ras-related C3 botulinum toxin substrate 1 (Rac1), attenuates glucose-stimulated insulin secretion in pancreatic β-cells
  gan: Sidarala, Vaibhav, et al.
  Cyhoeddwyd: (2015)
• Phagocyte-like NADPH oxidase (Nox2) promotes activation of p38MAPK in pancreatic β-cells under glucotoxic conditions: Evidence for a requisite role of Ras-related C3 botulinum toxin substrate 1 (Rac1)
  gan: Sidarala, Vaibhav, et al.
  Cyhoeddwyd: (2015)
• Glucotoxicity promotes aberrant activation and mislocalization of Ras-related C3 botulinum toxin substrate 1 [Rac1] and metabolic dysfunction in pancreatic islet β-cells: Reversal of such metabolic defects by metformin
  gan: Baidwan, Sartaj, et al.
  Cyhoeddwyd: (2017)
• NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model
  gan: Veluthakal, Rajakrishnan, et al.
  Cyhoeddwyd: (2016)
• The Regulatory Roles of Mitogen-Activated Protein Kinase (MAPK) Pathways in Health and Diabetes: Lessons Learned from the Pancreatic β-Cell
  gan: Sidarala, Vaibhav, et al.
  Cyhoeddwyd: (2017)