VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells

AIMS/HYPOTHESIS: Rho GTPases (Ras-related C3 botulinum toxin substrate 1 [Rac1] and cell division cycle 42 [Cdc42]) have been shown to regulate glucose-stimulated insulin secretion (GSIS) via cytoskeletal remodelling, trafficking and fusion of insulin-secretory granules with the plasma membrane. GTP...

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Detalhes bibliográficos
Publicado no:Diabetologia
Main Authors: Veluthakal, Rajakrishnan, Tunduguru, Ragadeepthi, Arora, Daleep Kumar, Sidarala, Vaibhav, Syeda, Khadija, Vlaar, Cornelis P., Thurmond, Debbie C., Kowluru, Anjaneyulu
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591202/
https://ncbi.nlm.nih.gov/pubmed/26224100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-015-3707-4
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