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Kinetic Basis for DNA Target Specificity of CRISPR-Cas12a
Class 2 CRISPR-Cas nucleases are programmable genome editing tools with promising applications in human health and disease. However, DNA cleavage at off-target sites that resemble the target sequence is a pervasive problem that remains poorly understood mechanistically. Here, we use quantitative kin...
Tallennettuna:
| Julkaisussa: | Mol Cell |
|---|---|
| Päätekijät: | , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2018
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6679935/ https://ncbi.nlm.nih.gov/pubmed/30078724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.06.043 |
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