The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome

The receptor-interacting protein 1 (RIPK1)/RIPK3 kinases play important roles in necroptosis that is closely linked to inflammatory response. Although the activation of necroptosis is well characterized, how necroptosis is tuned down is largely unknown. Here, we found that Parkin (also known as PARK...

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Pubblicato in:Nat Cell Biol
Autori principali: Lee, Seung Baek, Kim, Jung Jin, Han, Sang-Ah, Fan, Yingfang, Guo, Li-Sha, Aziz, Khaled, Nowsheen, Somaira, Kim, Sung Sun, Park, Seon-Young, Luo, Qifeng, Chung, Jin Ook, Choi, Sung Il, Aziz, Asef, Yin, Ping, Tong, Seo-Yun, Fiesel, Fabienne C., Springer, Wolfdieter, Zhang, Jin-San, Lou, Zhenkun
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679774/
https://ncbi.nlm.nih.gov/pubmed/31358971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0356-8
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