The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome

The receptor-interacting protein 1 (RIPK1)/RIPK3 kinases play important roles in necroptosis that is closely linked to inflammatory response. Although the activation of necroptosis is well characterized, how necroptosis is tuned down is largely unknown. Here, we found that Parkin (also known as PARK...

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Gepubliceerd in:Nat Cell Biol
Hoofdauteurs: Lee, Seung Baek, Kim, Jung Jin, Han, Sang-Ah, Fan, Yingfang, Guo, Li-Sha, Aziz, Khaled, Nowsheen, Somaira, Kim, Sung Sun, Park, Seon-Young, Luo, Qifeng, Chung, Jin Ook, Choi, Sung Il, Aziz, Asef, Yin, Ping, Tong, Seo-Yun, Fiesel, Fabienne C., Springer, Wolfdieter, Zhang, Jin-San, Lou, Zhenkun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679774/
https://ncbi.nlm.nih.gov/pubmed/31358971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0356-8
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