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Conserved properties of genetic architecture of renal and fat transcriptomes in rat models of insulin resistance

To define renal molecular mechanisms that are affected by permanent hyperglycaemia and might promote phenotypes relevant to diabetic nephropathy, we carried out linkage analysis of genome-wide gene transcription in the kidneys of F2 offspring from the Goto-Kakizaki (GK) rat model of type 2 diabetes...

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Detalles Bibliográficos
Publicado en:Dis Model Mech
Main Authors: Otto, Georg W., Kaisaki, Pamela J., Brial, Francois, Le Lay, Aurélie, Cazier, Jean-Baptiste, Mott, Richard, Gauguier, Dominique
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists Ltd 2019
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679378/
https://ncbi.nlm.nih.gov/pubmed/31213483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.038539
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