Comparative Assessment of Antitumor Effects and Autophagy Induction as a Resistance Mechanism by Cytotoxics and EZH2 Inhibition in INI1-Negative Epithelioid Sarcoma Patient-Derived Xenograft

Epithelioid sarcoma (ES) is a rare mesenchymal malignancy marked by SMARCB1/INI1 deficiency. Retrospective clinical data report on the activity of anthracycline- and gemcitabine-based regimens. EZH2 inhibitors are currently being tested in clinical trials. Since comparisons of these agents are unlik...

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Published in:Cancers (Basel)
Main Authors: Stacchiotti, Silvia, Zuco, Valentina, Tortoreto, Monica, Cominetti, Denis, Frezza, Anna Maria, Percio, Stefano, Indio, Valentina, Barisella, Marta, Monti, Valentina, Brich, Silvia, Astolfi, Annalisa, Colombo, Chiara, Pasquali, Sandro, Folini, Marco, Gounder, Mrinal M., Pantaleo, Maria A., Collini, Paola, Dei Tos, Angelo Paolo, Casali, Paolo Giovanni, Gronchi, Alessandro, Zaffaroni, Nadia
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6678245/
https://ncbi.nlm.nih.gov/pubmed/31331120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11071015
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