IRF1 inhibits antitumor immunity through the upregulation of PD-L1 in the tumor cell: Tumor promoting activity of IRF1

Multiple studies have associated the transcription factor IRF1 with tumor suppressive activities. Here we report an opposite tumor cell–intrinsic function of IRF1 in promoting tumor growth. IRF1-deficient tumor cells showed reduced tumor growth in MC38 and CT26 colon carcinoma and B16 melanoma mouse...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Shao, Lulu, Hou, Weizhou, Scharping, Nicole E., Vendetti, Frank P., Srivastava, Rashmi, Roy, Chandra Nath, Menk, Ashley V., Wang, Yiyang, Chauvin, Joe-Marc, Karukonda, Pooja, Thorne, Stephen H., Hornung, Veit, Zarour, Hassane M., Bakkenist, Christopher J., Delgoffe, Greg M., Sarkar, Saumendra N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6677597/
https://ncbi.nlm.nih.gov/pubmed/31239318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-18-0711
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados