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IL-10 and PD-1 cooperate to limit the activity of tumor-specific CD8(+) T cells

Immune checkpoint inhibitors show great promise as therapy for advanced melanoma, heightening the need to determine the most effective use of these agents. Here, we report that programmed death-1(high) (PD-1(high)) tumor antigen (TA)-specific CD8(+) T cells present at periphery and at tumor sites in...

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Detaylı Bibliyografya
Yayımlandı:Cancer Res
Asıl Yazarlar: Sun, Zhaojun, Fourcade, Julien, Pagliano, Ornella, Chauvin, Joe-Marc, Sander, Cindy, Kirkwood, John M., Zarour, Hassane M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4401638/
https://ncbi.nlm.nih.gov/pubmed/25720800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-3016
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