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TIGIT and PD-1 impair tumor antigen–specific CD8(+) T cells in melanoma patients
T cell Ig and ITIM domain (TIGIT) is an inhibitory receptor expressed by activated T cells, Tregs, and NK cells. Here, we determined that TIGIT is upregulated on tumor antigen–specific (TA-specific) CD8(+) T cells and CD8(+) tumor-infiltrating lymphocytes (TILs) from patients with melanoma, and thes...
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| Опубликовано в: : | J Clin Invest |
|---|---|
| Главные авторы: | , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4463210/ https://ncbi.nlm.nih.gov/pubmed/25866972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI80445 |
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