CD8+ T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1

Cytotoxic T cells that are present in tumors and capable of recognizing tumor epitopes are nevertheless generally impotent in eliciting tumor rejection. Thus, identifying the immune escape mechanisms responsible for inducing tumor-specific CD8+ T cell dysfunction may reveal effective strategies for...

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Bibliographic Details
Main Authors: Fourcade, Julien, Sun, Zhaojun, Pagliano, Ornella, Guillaume, Philippe, Luescher, Immanuel F., Sander, Cindy, Kirkwood, John M., Olive, Daniel, Kuchroo, Vijay, Zarour, Hassane M.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288235/
https://ncbi.nlm.nih.gov/pubmed/22205715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-2637
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