High affinity CXCR4 inhibitors generated by linking low affinity peptides

G-protein coupled receptors (GPCRs) are implicated in many diseases and attractive targets for drug discovery. Peptide fragments derived from protein ligands of GPCRs are commonly used as probes of GPCR function and as leads for drug development. However, these peptide fragments lack the structural...

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Dades bibliogràfiques
Publicat a:Eur J Med Chem
Autors principals: Zhang, Chaozai, Huang, Lina S., Zhu, Ruohan, Meng, Qian, Zhu, Siyu, Xu, Yan, Zhang, Huijun, Fang, Xiong, Zhang, Xingquan, Zhou, Jiao, Schooley, Robert T., Yang, Xiaohong, Huang, Ziwei, An, Jing
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6677133/
https://ncbi.nlm.nih.gov/pubmed/30978562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2019.03.056
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