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High affinity CXCR4 inhibitors generated by linking low affinity peptides

G-protein coupled receptors (GPCRs) are implicated in many diseases and attractive targets for drug discovery. Peptide fragments derived from protein ligands of GPCRs are commonly used as probes of GPCR function and as leads for drug development. However, these peptide fragments lack the structural...

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הוצא לאור ב:	Eur J Med Chem
Main Authors:	Zhang, Chaozai, Huang, Lina S., Zhu, Ruohan, Meng, Qian, Zhu, Siyu, Xu, Yan, Zhang, Huijun, Fang, Xiong, Zhang, Xingquan, Zhou, Jiao, Schooley, Robert T., Yang, Xiaohong, Huang, Ziwei, An, Jing
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2019
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6677133/ https://ncbi.nlm.nih.gov/pubmed/30978562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2019.03.056
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High affinity CXCR4 inhibitors generated by linking low affinity peptides

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