High affinity CXCR4 inhibitors generated by linking low affinity peptides

G-protein coupled receptors (GPCRs) are implicated in many diseases and attractive targets for drug discovery. Peptide fragments derived from protein ligands of GPCRs are commonly used as probes of GPCR function and as leads for drug development. However, these peptide fragments lack the structural...

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Опубликовано в: :Eur J Med Chem
Главные авторы: Zhang, Chaozai, Huang, Lina S., Zhu, Ruohan, Meng, Qian, Zhu, Siyu, Xu, Yan, Zhang, Huijun, Fang, Xiong, Zhang, Xingquan, Zhou, Jiao, Schooley, Robert T., Yang, Xiaohong, Huang, Ziwei, An, Jing
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6677133/
https://ncbi.nlm.nih.gov/pubmed/30978562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2019.03.056
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