High affinity CXCR4 inhibitors generated by linking low affinity peptides

G-protein coupled receptors (GPCRs) are implicated in many diseases and attractive targets for drug discovery. Peptide fragments derived from protein ligands of GPCRs are commonly used as probes of GPCR function and as leads for drug development. However, these peptide fragments lack the structural...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Zhang, Chaozai, Huang, Lina S., Zhu, Ruohan, Meng, Qian, Zhu, Siyu, Xu, Yan, Zhang, Huijun, Fang, Xiong, Zhang, Xingquan, Zhou, Jiao, Schooley, Robert T., Yang, Xiaohong, Huang, Ziwei, An, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6677133/
https://ncbi.nlm.nih.gov/pubmed/30978562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2019.03.056
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