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Lysophospholipids induce Fibrillation of the Repeat domain of Pmel17 through intermediate core-shell structures
Lipids often play an important role in the initial steps of fibrillation. The melanosomal protein Pmel17 forms amyloid in vivo and contains a highly amyloidogenic Repeat domain (RPT), important for melanin biosynthesis. RPT fibrillation is influenced by two lysolipids, the anionic lysophosphatidylgl...
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| Publicado no: | Biochim Biophys Acta Proteins Proteom |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6677129/ https://ncbi.nlm.nih.gov/pubmed/30471451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2018.11.007 |
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