Modeling RNA-binding protein specificity in vivo by precisely registering protein-RNA crosslink sites

RNA-binding proteins (RBPs) regulate post-transcriptional gene expression by recognizing short and degenerate sequence motifs in their target transcripts, but precisely defining their binding specificity remains challenging. Crosslinking and immunoprecipitation (CLIP) allows for mapping of the exact...

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Udgivet i:Mol Cell
Main Authors: Feng, Huijuan, Bao, Suying, Rahman, Mohammad Alinoor, Weyn-Vanhentenryck, Sebastien M., Khan, Aziz, Wong, Justin, Shah, Ankeeta, Flynn, Elise D., Krainer, Adrian R., Zhang, Chaolin
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6676488/
https://ncbi.nlm.nih.gov/pubmed/31226278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.02.002
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