BRD4 inhibitor and histone deacetylase inhibitor synergistically inhibit the proliferation of gallbladder cancer in vitro and in vivo

Gallbladder cancer (GBC) is the most common malignancy of the bile duct and has a high mortality rate. Here, we demonstrated that BRD4 inhibitor JQ1 and histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) synergistically inhibited the GBC cells in vitro and in vivo. Our results show...

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Detalles Bibliográficos
Publicado en:Cancer Sci
Main Authors: Liu, Shilei, Li, Fengnan, Pan, Lijia, Yang, Ziyi, Shu, Yijun, Lv, Wenjie, Dong, Ping, Gong, Wei
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6676267/
https://ncbi.nlm.nih.gov/pubmed/31215139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14102
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