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BRD4 inhibitor and histone deacetylase inhibitor synergistically inhibit the proliferation of gallbladder cancer in vitro and in vivo

Gallbladder cancer (GBC) is the most common malignancy of the bile duct and has a high mortality rate. Here, we demonstrated that BRD4 inhibitor JQ1 and histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) synergistically inhibited the GBC cells in vitro and in vivo. Our results show...

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Bibliografski detalji
Izdano u:Cancer Sci
Glavni autori: Liu, Shilei, Li, Fengnan, Pan, Lijia, Yang, Ziyi, Shu, Yijun, Lv, Wenjie, Dong, Ping, Gong, Wei
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6676267/
https://ncbi.nlm.nih.gov/pubmed/31215139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14102
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