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Accumulation of Amyloid Precursor Protein in the Mitochondrial Import Channels of Human Alzheimer’s Disease Brain Is Associated with Mitochondrial Dysfunction

Mitochondrial dysfunction is one of the major intracellular lesions of Alzheimer’s disease (AD). However, the causative factors involved in the mitochondrial dysfunction in human AD are not well understood. Here we report that nonglycosylated full-length and C-terminal truncated amyloid precursor pr...

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Pubblicato in:J Neurosci
Autori principali: Devi, Latha, Prabhu, Badanavalu M., Galati, Domenico F., Avadhani, Narayan G., Anandatheerthavarada, Hindupur K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675337/
https://ncbi.nlm.nih.gov/pubmed/16943564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1469-06.2006
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