Small, Nonpeptide p75(NTR) Ligands Induce Survival Signaling and Inhibit proNGF-Induced Death

Studies showing that neurotrophin binding to p75(NTR) can promote cell survival in the absence of Trk (tropomyosin-related kinase) receptors, together with recent structural data indicating that NGF may bind to p75(NTR) in a monovalent manner, raise the possibility that small molecule p75(NTR) ligan...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Massa, Stephen M., Xie, Youmei, Yang, Tao, Harrington, Anthony W., Kim, Mi Lyang, Yoon, Sung Ok, Kraemer, Rosemary, Moore, Laura A., Hempstead, Barbara L., Longo, Frank M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2006
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675309/
https://ncbi.nlm.nih.gov/pubmed/16707781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3547-05.2006
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