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Simvastatin causes pulmonary artery relaxation by blocking smooth muscle ROCK and calcium channels: Evidence for an endothelium-independent mechanism

Simvastatin reduces pulmonary arterial pressure and right ventricular hypertrophy in animal models of pulmonary arterial hypertension (PAH) and is thought to restore endothelial dysfunction. In vivo effects of drugs are complicated by several factors and little is known of the direct effects of stat...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:PLoS One
मुख्य लेखकों: Absi, Mais, Eid, Basma G., Ashton, Nick, Hart, George, Gurney, Alison M.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2019
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675113/
https://ncbi.nlm.nih.gov/pubmed/31369604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0220473
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