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Zinc pyrithione activates K(+) channels and hyperpolarizes the membrane of rat pulmonary artery smooth muscle cells
The membrane potential helps determine pulmonary artery smooth muscle cell (PASMC) contraction. The Kv7 channel activators, retigabine and flupirtine, are thought to dilate pulmonary arteries by hyperpolarising PASMC. Zinc pyrithione activates Kv7 channels by a mechanism distinct from retigabine and...
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| Publicado no: | PLoS One |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5824988/ https://ncbi.nlm.nih.gov/pubmed/29474372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192699 |
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