Simvastatin causes pulmonary artery relaxation by blocking smooth muscle ROCK and calcium channels: Evidence for an endothelium-independent mechanism

Simvastatin reduces pulmonary arterial pressure and right ventricular hypertrophy in animal models of pulmonary arterial hypertension (PAH) and is thought to restore endothelial dysfunction. In vivo effects of drugs are complicated by several factors and little is known of the direct effects of stat...

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Vydáno v:PLoS One
Hlavní autoři: Absi, Mais, Eid, Basma G., Ashton, Nick, Hart, George, Gurney, Alison M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675113/
https://ncbi.nlm.nih.gov/pubmed/31369604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0220473
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