Expression of Mutated Mouse Myocilin Induces Open-Angle Glaucoma in Transgenic Mice

We developed a genetic mouse model of open-angle glaucoma by expression of mutated mouse myocilin (Myoc) in transgenic (Tg) mice. The Tyr423His point mutation, corresponding to the severe glaucoma-causing Tyr437His mutation in the human MYOC gene, was introduced into bacterial artificial chromosome...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Senatorov, Vladimir, Malyukova, Irina, Fariss, Robert, Wawrousek, Eric F., Swaminathan, Srividya, Sharan, Shyam K., Tomarev, Stanislav
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674879/
https://ncbi.nlm.nih.gov/pubmed/17108164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3020-06.2006
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