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Structure of the Catalytic Pore of γ-Secretase Probed by the Accessibility of Substituted Cysteines
Several single-span membrane proteins are cleaved within their transmembrane domains (TMDs) by intramembrane-cleaving proteases, although the structure of the active site executing intramembrane cleavage remains unknown. Here we use the substituted cysteine accessibility method to examine the struct...
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| Publicat a: | J Neurosci |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Society for Neuroscience
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6674866/ https://ncbi.nlm.nih.gov/pubmed/17108181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3614-06.2006 |
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