Structure of the Catalytic Pore of γ-Secretase Probed by the Accessibility of Substituted Cysteines

Several single-span membrane proteins are cleaved within their transmembrane domains (TMDs) by intramembrane-cleaving proteases, although the structure of the active site executing intramembrane cleavage remains unknown. Here we use the substituted cysteine accessibility method to examine the struct...

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Vydáno v:J Neurosci
Hlavní autoři: Sato, Chihiro, Morohashi, Yuichi, Tomita, Taisuke, Iwatsubo, Takeshi
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674866/
https://ncbi.nlm.nih.gov/pubmed/17108181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3614-06.2006
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