Calpain-Cleaved Collapsin Response Mediator Protein-3 Induces Neuronal Death after Glutamate Toxicity and Cerebral Ischemia

Collapsin response mediator proteins (CRMPs) mediate growth cone collapse during development, but their roles in adult brains are not clear. Here we report the findings that the full-length CRMP-3 (p63) is a direct target of calpain that cleaves CRMP-3 at the N terminus (+76 amino acid). Interesting...

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Publié dans:J Neurosci
Auteurs principaux: Hou, Sheng T., Jiang, Susan X., Desbois, Angele, Huang, Deqi, Kelly, John, Tessier, Luc, Karchewski, Laurie, Kappler, Joachim
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2006
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674801/
https://ncbi.nlm.nih.gov/pubmed/16495451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4485-05.2006
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