Identification of a GABA(A) Receptor Anesthetic Binding Site at Subunit Interfaces by Photolabeling with an Etomidate Analog

General anesthetics, including etomidate, act by binding to and enhancing the function of GABA type A receptors (GABA(A)Rs), which mediate inhibitory neurotransmission in the brain. Here, we used a radiolabeled, photoreactive etomidate analog ([(3)H]azietomidate), which retains anesthetic potency in...

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Publicat a:J Neurosci
Autors principals: Li, Guo-Dong, Chiara, David C., Sawyer, Gregory W., Husain, S. Shaukat, Olsen, Richard W., Cohen, Jonathan B.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2006
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674783/
https://ncbi.nlm.nih.gov/pubmed/17093081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3467-06.2006
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