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Impaired Inactivation Gate Stabilization Predicts Increased Persistent Current for an Epilepsy-Associated SCN1A Mutation

Mutations in SCN1A (encoding the neuronal voltage-gated sodium channel α(1) subunit, Na(V)1.1, or SCN1A) are associated with genetic epilepsy syndromes including generalized epilepsy with febrile seizures plus (GEFS+) and severe myoclonic epilepsy of infancy. Here, we present the formulation and use...

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Dades bibliogràfiques
Publicat a:J Neurosci
Autors principals: Kahlig, Kristopher M., Misra, Sunita N., George, Alfred L.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674674/
https://ncbi.nlm.nih.gov/pubmed/17065438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3378-06.2006
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