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Polyglutamine Proteins at the Pathogenic Threshold Display Neuron-Specific Aggregation in a Pan-Neuronal Caenorhabditis elegans Model

The basis of neuron-specific pathogenesis, resulting from the expression of misfolded proteins, is poorly understood and of central importance to an understanding of the cell-type specificity of neurodegenerative disease. In this study, we developed a new model for neuron-specific polyQ pathogenesis...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Brignull, Heather R., Moore, Finola E., Tang, Stephanie J., Morimoto, Richard I.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674286/
https://ncbi.nlm.nih.gov/pubmed/16855087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0990-06.2006
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