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β-Amyloid Accumulation Impairs Multivesicular Body Sorting by Inhibiting the Ubiquitin-Proteasome System
Increasing evidence links intraneuronal β-amyloid (Aβ(42)) accumulation with the pathogenesis of Alzheimer’s disease (AD). In Aβ precursor protein (APP) mutant transgenic mice and in human AD brain, progressive intraneuronal accumulation of Aβ(42) occurs especially in multivesicular bodies (MVBs). W...
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| I publikationen: | J Neurosci |
|---|---|
| Huvudupphovsmän: | , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Society for Neuroscience
2006
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6673997/ https://ncbi.nlm.nih.gov/pubmed/16624948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5078-05.2006 |
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