Deletion of the Ubiquitin Ligase CHIP Leads to the Accumulation, But Not the Aggregation, of Both Endogenous Phospho- and Caspase-3-Cleaved Tau Species

Accumulation of the microtubule-associated protein tau into neurofibrillary lesions is a pathological consequence of several neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. Hereditary mutations in the MAPT gene were shown to promote the formation of struc...

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Publicado no:J Neurosci
Principais autores: Dickey, Chad A., Yue, Mei, Lin, Wen-Lang, Dickson, Dennis W., Dunmore, Judith H., Lee, Wing C., Zehr, Cynthia, West, Gemma, Cao, Songsong, Clark, Amber M. K., Caldwell, Guy A., Caldwell, Kim A., Eckman, Christopher, Patterson, Cam, Hutton, Michael, Petrucelli, Leonard
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673930/
https://ncbi.nlm.nih.gov/pubmed/16807328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0746-06.2006
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