The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

A primary pathologic component of Alzheimer’s disease (AD) is the formation of neurofibrillary tangles composed of hyperphosphorylated tau (p-tau). Expediting the removal of these p-tau species may be a relevant therapeutic strategy. Here we report that inhibition of Hsp90 led to decreases in p-tau...

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Main Authors: Dickey, Chad A., Kamal, Adeela, Lundgren, Karen, Klosak, Natalia, Bailey, Rachel M., Dunmore, Judith, Ash, Peter, Shoraka, Sareh, Zlatkovic, Jelena, Eckman, Christopher B., Patterson, Cam, Dickson, Dennis W., Nahman, N. Stanley, Hutton, Michael, Burrows, Francis, Petrucelli, Leonard
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1794119/
https://ncbi.nlm.nih.gov/pubmed/17304350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29715
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