Enhanced Accumulation of Phosphorylated α-Synuclein and Elevated β-Amyloid 42/40 Ratio Caused by Expression of the Presenilin-1 ΔT440 Mutant Associated with Familial Lewy Body Disease and Variant Alzheimer's Disease

Mutations in the PSEN1 gene encoding presenilin 1 (PS1) are linked to a vast majority of pedigrees with early-onset, autosomal dominant forms of familial Alzheimer's disease (FAD). Lewy body (LB) pathology is frequently found in the brains of FAD patients harboring PSEN1 mutations. We recently...

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Publicado no:J Neurosci
Main Authors: Kaneko, Hiroyuki, Kakita, Akiyoshi, Kasuga, Kensaku, Nozaki, Hiroaki, Ishikawa, Atsushi, Miyashita, Akinori, Kuwano, Ryozo, Ito, Genta, Iwatsubo, Takeshi, Takahashi, Hitoshi, Nishizawa, Masatoyo, Onodera, Osamu, Sisodia, Sangram S., Ikeuchi, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673391/
https://ncbi.nlm.nih.gov/pubmed/18045903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4244-07.2007
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