Evidence for a Common Founder and Clinical Characteristics of Japanese Families with the MAPT R406W Mutation

Background/Aim: Mutations in MAPT cause frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17). Patients with the MAPT R406W mutation were reported to show phenotypic heterogeneity in different ethnic backgrounds. We here report the clinical and genetic characteristics of Japane...

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Main Authors: Takeshi Ikeuchi, Toru Imamura, Yasuhiro Kawase, Yoshimi Kitade, Miyuki Tsuchiya, Takayoshi Tokutake, Kensaku Kasuga, Ryuji Yajima, Tamao Tsukie, Akinori Miyashita, Morihiro Sugishita, Ryozo Kuwano, Masatoyo Nishizawa
Formato: Artigo
Idioma:Inglês
Publicado em: Karger Publishers 2011-09-01
Colecção:Dementia and Geriatric Cognitive Disorders Extra
Assuntos:
Amnestic syndrome
Familial dementia
Founder effect
FTDP-17
MAPT mutation
Acesso em linha:http://www.karger.com/Article/FullText/331243
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