Loss-of-Function of Human PINK1 Results in Mitochondrial Pathology and Can Be Rescued by Parkin

Degeneration of dopaminergic neurons in the substantia nigra is characteristic for Parkinson's disease (PD), the second most common neurodegenerative disorder. Mitochondrial dysfunction is believed to contribute to the etiology of PD. Although most cases are sporadic, recent evidence points to...

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Vydáno v:J Neurosci
Hlavní autoři: Exner, Nicole, Treske, Bettina, Paquet, Dominik, Holmström, Kira, Schiesling, Carola, Gispert, Suzana, Carballo-Carbajal, Iria, Berg, Daniela, Hoepken, Hans-Hermann, Gasser, Thomas, Krüger, Rejko, Winklhofer, Konstanze F., Vogel, Frank, Reichert, Andreas S., Auburger, Georg, Kahle, Philipp J., Schmid, Bettina, Haass, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673250/
https://ncbi.nlm.nih.gov/pubmed/17989306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0719-07.2007
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