Phosphatidylinositol 3-Akt-Kinase-Dependent Phosphorylation of p21(Waf1/Cip1) as a Novel Mechanism of Neuroprotection by Glucocorticoids

The role of glucocorticoids in the regulation of apoptosis remains incongruous. Here, we demonstrate that corticosterone protects neurons from apoptosis by a mechanism involving the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). In primary cortical neurons, corticosterone leads to a dose- and Akt...

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Publicado en:J Neurosci
Main Authors: Harms, Christoph, Albrecht, Katharina, Harms, Ulrike, Seidel, Kerstin, Hauck, Ludger, Baldinger, Tina, Hübner, Denise, Kronenberg, Golo, An, Junfeng, Ruscher, Karsten, Meisel, Andreas, Dirnagl, Ulrich, von Harsdorf, Rüdiger, Endres, Matthias, Hörtnagl, Heide
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2007
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672985/
https://ncbi.nlm.nih.gov/pubmed/17460069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5110-06.2007
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