Mild Cerebral Ischemia Induces Loss of Cyclin-Dependent Kinase Inhibitors and Activation of Cell Cycle Machinery before Delayed Neuronal Cell Death

After mild ischemic insults, many neurons undergo delayed neuronal death. Aberrant activation of the cell cycle machinery is thought to contribute to apoptosis in various conditions including ischemia. We demonstrate that loss of endogenous cyclin-dependent kinase (Cdk) inhibitor p16(INK4a) is an ea...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Katchanov, Juri, Harms, Christoph, Gertz, Karen, Hauck, Ludger, Waeber, Christian, Hirt, Lorenz, Priller, Josef, von Harsdorf, Rüdiger, Brück, Wolfgang, Hörtnagl, Heide, Dirnagl, Ulrich, Bhide, Pradeep G., Endres, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2001
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762829/
https://ncbi.nlm.nih.gov/pubmed/11438580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-14-05045.2001
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