Mild Cerebral Ischemia Induces Loss of Cyclin-Dependent Kinase Inhibitors and Activation of Cell Cycle Machinery before Delayed Neuronal Cell Death

After mild ischemic insults, many neurons undergo delayed neuronal death. Aberrant activation of the cell cycle machinery is thought to contribute to apoptosis in various conditions including ischemia. We demonstrate that loss of endogenous cyclin-dependent kinase (Cdk) inhibitor p16(INK4a) is an ea...

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Pubblicato in:J Neurosci
Autori principali: Katchanov, Juri, Harms, Christoph, Gertz, Karen, Hauck, Ludger, Waeber, Christian, Hirt, Lorenz, Priller, Josef, von Harsdorf, Rüdiger, Brück, Wolfgang, Hörtnagl, Heide, Dirnagl, Ulrich, Bhide, Pradeep G., Endres, Matthias
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762829/
https://ncbi.nlm.nih.gov/pubmed/11438580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-14-05045.2001
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