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Defective Retrotranslocation Causes Loss of Anti-Bax Function in Human Familial Prion Protein Mutants
Prion protein (PrP) inhibits the activation of proapoptotic Bax in primary human neurons and MCF-7 cells. Because neuronal apoptosis occurs in human prion diseases, here we examine the anti-Bax function of familial PrP mutants. All Creutzfeldt-Jakob disease and fatal familial insomnia-associated pri...
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| Publié dans: | J Neurosci |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Society for Neuroscience
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6672383/ https://ncbi.nlm.nih.gov/pubmed/17494694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0957-07.2007 |
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