Defective Retrotranslocation Causes Loss of Anti-Bax Function in Human Familial Prion Protein Mutants

Prion protein (PrP) inhibits the activation of proapoptotic Bax in primary human neurons and MCF-7 cells. Because neuronal apoptosis occurs in human prion diseases, here we examine the anti-Bax function of familial PrP mutants. All Creutzfeldt-Jakob disease and fatal familial insomnia-associated pri...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Jodoin, Julie, Laroche-Pierre, Stéphanie, Goodyer, Cynthia G., LeBlanc, Andréa C.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672383/
https://ncbi.nlm.nih.gov/pubmed/17494694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0957-07.2007
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