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CYTOSOLIC PRION PROTEIN IS THE PREDOMINANT ANTI-BAX PRION PROTEIN FORM: EXCLUSION OF TRANSMEMBRANE AND SECRETED PRION PROTEIN FORMS IN THE ANTI-BAX FUNCTION

Prion protein (PrP) prevents Bax-mediated cell death by inhibiting the initial Bax conformational change that converts cytosolic Bax into a pro-apoptotic protein. PrP is mostly a glycophosphatidylinositol-anchored cell surface protein but it is also retrotranslocated into cytosolic PrP (CyPrP) or ca...

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Detalhes bibliográficos
Main Authors: Lin, David T. S., Jodoin, Julie, Baril, Michaël, Goodyer, Cynthia G., LeBlanc, Andréa C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662133/
https://ncbi.nlm.nih.gov/pubmed/18590778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2008.05.022
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