ABCA1- and ABCG1-mediated cholesterol efflux capacity of cerebrospinal fluid is impaired in Alzheimer’s disease

HDL-like particles in human cerebrospinal fluid (CSF) promote the efflux of cholesterol from astrocytes toward the neurons that rely on this supply for their functions. We evaluated whether cell cholesterol efflux capacity of CSF (CSF-CEC) is impaired in Alzheimer’s disease (AD) by analyzing AD (n =...

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Vydáno v:J Lipid Res
Hlavní autoři: Marchi, Cinzia, Adorni, Maria Pia, Caffarra, Paolo, Ronda, Nicoletta, Spallazzi, Marco, Barocco, Federica, Galimberti, Daniela, Bernini, Franco, Zimetti, Francesca
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2019
Témata:
Patient-Oriented and Epidemiological Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672040/
https://ncbi.nlm.nih.gov/pubmed/31167810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.P091033
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