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ABCA1- and ABCG1-mediated cholesterol efflux capacity of cerebrospinal fluid is impaired in Alzheimer’s disease

HDL-like particles in human cerebrospinal fluid (CSF) promote the efflux of cholesterol from astrocytes toward the neurons that rely on this supply for their functions. We evaluated whether cell cholesterol efflux capacity of CSF (CSF-CEC) is impaired in Alzheimer’s disease (AD) by analyzing AD (n =...

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Bibliografski detalji
Izdano u:J Lipid Res
Glavni autori: Marchi, Cinzia, Adorni, Maria Pia, Caffarra, Paolo, Ronda, Nicoletta, Spallazzi, Marco, Barocco, Federica, Galimberti, Daniela, Bernini, Franco, Zimetti, Francesca
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Biochemistry and Molecular Biology 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672040/
https://ncbi.nlm.nih.gov/pubmed/31167810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.P091033
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