ABCA1- and ABCG1-mediated cholesterol efflux capacity of cerebrospinal fluid is impaired in Alzheimer’s disease

HDL-like particles in human cerebrospinal fluid (CSF) promote the efflux of cholesterol from astrocytes toward the neurons that rely on this supply for their functions. We evaluated whether cell cholesterol efflux capacity of CSF (CSF-CEC) is impaired in Alzheimer’s disease (AD) by analyzing AD (n =...

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Библиографические подробности
Опубликовано в: :J Lipid Res
Главные авторы: Marchi, Cinzia, Adorni, Maria Pia, Caffarra, Paolo, Ronda, Nicoletta, Spallazzi, Marco, Barocco, Federica, Galimberti, Daniela, Bernini, Franco, Zimetti, Francesca
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Biochemistry and Molecular Biology 2019
Предметы:
Patient-Oriented and Epidemiological Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672040/
https://ncbi.nlm.nih.gov/pubmed/31167810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.P091033
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