Production of seedable Amyloid-β peptides in model of prion diseases upon PrP(Sc)-induced PDK1 overactivation

The presence of amyloid beta (Aβ) plaques in the brain of some individuals with Creutzfeldt-Jakob or Gertsmann-Straussler-Scheinker diseases suggests that pathogenic prions (PrP(Sc)) would have stimulated the production and deposition of Aβ peptides. We here show in prion-infected neurons and mice t...

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Bibliografische gegevens
Gepubliceerd in:Nat Commun
Hoofdauteurs: Ezpeleta, Juliette, Baudouin, Vincent, Arellano-Anaya, Zaira E., Boudet-Devaud, François, Pietri, Mathéa, Baudry, Anne, Haeberlé, Anne-Marie, Bailly, Yannick, Kellermann, Odile, Launay, Jean-Marie, Schneider, Benoit
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672003/
https://ncbi.nlm.nih.gov/pubmed/31371707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11333-3
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